Pharmacokinetics
Biopharmaceutics
Screening of drug absorption potential
학력
(Ph.D.) University of British Columbia, Canada (1989)
약력/경력
1997~ : Associate and Full Professor,
Sungkyunkwan University
1991~1997 : Assistant Professor,
University of South Carolina
1989~1991 : Postdoctoral Fellow,
University of Kentucky
학술지 논문
(2018)
Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system.
JOURNAL OF CONTROLLED RELEASE.
286,
1
(2018)
Alterations of Gefitinib Pharmacokinetics by Co-administration of Herbal Medications in Rats.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE.
24,
6
(2018)
Effects of Phytochemical P-Glycoprotein Modulators on the Pharmacokinetics and Tissue Distribution of Doxorubicin in Mice.
MOLECULES.
23,
2
(2017)
Doxorubicin and paclitaxel co-bound lactosylated albumin nanoparticles having targetability to hepatocellular carcinoma.
COLLOIDS AND SURFACES B-BIOINTERFACES.
152,
4
(2017)
Development of a Physiologically Relevant Population Pharmacokinetic in Vitro-in Vivo Correlation Approach for Designing Extended-Release Oral Dosage Formulation.
MOLECULAR PHARMACEUTICS.
14,
1
(2017)
Simple and sensitive HPLC-UV method for determination of bexarotene in rat plasma.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES.
1040,
(2016)
Placental transfer and mammary excretion of a novel angiotensin receptor blocker fimasartan in rats.
BMC Pharmacology and Toxicology.
17,
1
(2015)
Exposure assessment of epidermal growth factor to various tissues in mice after intravenous and subcutaneous administration.
JOURNAL OF PHARMACY AND PHARMACOLOGY.
67,
11
(2015)
A sensitive LC-ESI-MS/MS method for the quantification of avobenzone in rat plasma and skin layers: Application to a topical administration study.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES.
1003,
(2015)
Sensitive liquid chromatography-tandem mass spectrometry method for the simultaneous determination of benzyl butyl phthalate and its metabolites, monobenzyl phthalate and monobutyl phthalate, in rat plasma, urine, and various tissues collected from a toxicokinetic study.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY.
407,
24
(2015)
LC-APCI-MS/MS Quantification and Topical Bioavailability of Chloroacetamide in Rats.
JOURNAL OF CHROMATOGRAPHIC SCIENCE.
53,
7
(2015)
A novel in vitro permeability assay using three-dimensional cell culture system.
JOURNAL OF BIOTECHNOLOGY.
205,
(2015)
Simultaneous determination of phenoxyethanol and its major metabolite, phenoxyacetic acid, in rat biological matrices by LC-MS/MS with polarity switching: Application to ADME studies.
TALANTA.
144,
(2015)
In vivo absorption and disposition of alpha-cedrene, a sesquiterpene constituent of cedarwood oil, in female and male rats.
DRUG METABOLISM AND PHARMACOKINETICS.
30,
(2015)
Bioequivalence of tacrolimus formulations with different dynamic solubility and in-vitro dissolution profiles.
ARCHIVES OF PHARMACAL RESEARCH.
38,
1
(2014)
Pharmacokinetics and metabolite profiling of fimasartan, a novel antihypertensive agent, in rats.
XENOBIOTICA.
44,
10
(2014)
HPLC-MS/MS METHOD FOR THE PHARMACOKINETICS OF HOMOSALATE AFTER TOPICAL ADMINISTRATION IN RATS.
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES.
37,
17
(2014)
Translational Possibility of [F-18]Mefway to Image Serotonin 1A Receptors in Humans: Comparison With [F-18]FCWAY in Rodents.
SYNAPSE.
68,
12
(2014)
Quantitative Determination of Absorption and First-Pass Metabolism of Apicidin, a Potent Histone Deacetylase Inhibitor.
DRUG METABOLISM AND DISPOSITION.
42,
(2013)
Percutaneous absorption, disposition, and exposure assessment of homosalate, a UV filtering agent, in rats.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES.
77,
단행본
(2003)
독성학.
청구문화사.
공동
(1998)
임상약학.
신일상사.
공동
특허/프로그램
실리콘 흡착제를 이용하여 제조한 홍삼 발포정.
10-2012-0103499.
20150407.
대한민국
에틸아세테이트 및 아세토니트릴의 유기용매 혼합액을 이용한 액체-액체 추출법을 포함하는 약물 검출법.
2012-0103480.
20141022.
대한민국
경구 투여용 약물의 장관흡수율 및 뇌투과도 측정방법.
10-0629913.
20060922.
대한민국
약물의 뇌투과도 측정방법.
10-0629914.
20060922.
대한민국
학술회의논문
(2017)
Development of a PBPK model for di-2-ethylhexyl phthalate and its active metabolites, mono-2-ethylhexyl phthalate, mono-2-ethyl-5-hydroxyethyl phthalate and 2-ethyl-5-oxohexyl phthalate, in rats.
77th FIP World Congress of Pharmacy and Pharmaceutical Sciences 2017.
대한민국
(2017)
Integrated physiologically based pharmacokinetic modeling for dibutyl phthalate and benzyl butyl phthalate and theirs active metabolites, mono butyl phthalate and mono benzyl phthalate in rats.
77th FIP World Congress of Pharmacy and Pharmaceutical Sciences 2017.
대한민국
(2016)
Development of a physiologically relevant in vitro-in vivo correlation modeling approach for designing extended-release oral dosage form.
2016 Inernational conference of the KSPST.
대한민국
(2016)
In vitro dermal penetration study of methyl2-octynoate, a fragrance, across the excised rats skins.
International Conference on 70th Anniversary of the Pharmaceutical Society of Korea.
대한민국
(2016)
In vitro dermal penetration study of sodium nitrite, a fragrant stabilizer, across the excised rat skins.
International Conference on 70th Anniversary of the Pharmaceutical Society of Korea.
대한민국
(2016)
LC-MS/MS determination of monoethylhexyl phthalate, mono-(2-ethyl-5-hydroxyhexyl) phthalate and mono-(2-ethyl-5-oxo-hexyl)phthalate in rat plasma as the potential biomarkers of diethykhexyl phthalate.
International Conference on 70th Anniversary of the Pharmaceutical Society of Korea.
대한민국
(2016)
Pharmacokinetics of mono(2-ethyl-5-hydroxyhexyl)phthalate and mono(2-ethyl-5-oxo-hexyl)phthalate, biomarkers of di(2-ethylhexyl)phthalate, in rats.
International Conference on 70th Anniversary of the Pharmaceutical Society of Korea.
대한민국
(2016)
Study on the percutaneous absorption of the fragrant ingredient rose ketone-4 across the rat ski.
International Conference on 70th Anniversary of the Pharmaceutical Society of Korea.
대한민국
(2016)
Urinary excretion of monobenzyl phthalate, monobutyl phthalate and their glucuronide conjugates follwoing oral administration of benzylbutyl phthalate in rats.
International Conference on 70th Anniversary of the Pharmaceutical Society of Korea.
대한민국
(2016)
Development of a physiologically based pharmacokinetic model for benzyl butyl phthalate and its active metabolites, mono benzyl phathalate and mono butyl phthalate.
The 11th International ISSX Meeing.
대한민국
(2016)
Development of physiologically based pharmacokinetic model of di-butyl phthalate and its toxic metabolite mono-butyl phthalate in rats.
The 11th International ISSX Meeing.
대한민국
(2016)
Establishing a predictive IVIVC for a drug with strongly pH dependent dissolution kinetics via population pharmacokinetic modeling.
The 11th International ISSX Meeing.
대한민국
(2016)
LC-MS/MS assay of mono butyl phthalate, major toxic metabolite of di-butyl phthalate in rats.
The 11th International ISSX Meeing.
대한민국
(2016)
Toxicokinetics and tissue distribution of di-butyl phthalate and its major toxic metabolite, mono-butyl phthalate in rats.
The 11th International ISSX Meeing.
대한민국
(2015)
New population pharmacokinetic IVIVC modeling approach using baclofen.
2015 AAPS Annual Meeting.
미국
(2015)
Tissue targeting of doxorubicin using phytochemical transporter inhibitors.
2015 AAPS Annual Meeting.
미국
(2015)
Determination of tetrabromo-o-cresol by liquid chromatography tandem mass spectrometry and application to a dermal absorption study.
2015 대한약학회 추계학술대회.
대한민국
(2015)
Sensitive liquid chromatography-tandem mass spectrometry method for the determination of potassium sorbate and its application to a skin permeation study.
2015 대한약학회 추계학술대회.
대한민국
(2015)
Development of physiologically-based pharmacokinetic model of benzyl butyl phthalate and its active metabolite mono benzyl phthalate in rats.
2015 대한약학회 춘계학술대회.
대한민국
(2015)
Quantification of dromerizole by LC-MS/MS and application to an in vitro dermal absorption study.
2015 대한약학회 춘계학술대회.
대한민국
